This talk presents a control approach for a class of Chemical Reaction Networks (CRNs) that are coupled through phisically motivated interconnections. First, control-oriented models are proposed for interconnected CRNs. Second, based on these models, a distributed control method is introduced which assures that each CRN in the interconnected system can be driven into a desired fixed point (setpoint) regardless the delay in the interconnections. The proposed algorithm is also augmented with a disturbance attenuation term to compensate the effect of unknown input disturbances on setpoint tracking performance. The control design applies the theory of passive systems and methods developed for multi-agent systems. Simulation results are provided to show the applicability of the proposed control method.